Skylar Brandt was born in Purchase, New York and began her training at the age of six at Scarsdale Ballet Studio. She attended the Jacqueline Kennedy Onassis School at American Ballet Theatre from 2005-2009. Brandt was a silver medalist at Youth America Grand Prix in 2004 and 2008.

Brandt joined ABT II in 2009, became an apprentice with ABT in 2010, and joined the corps de ballet in 2011. She was promoted to Soloist in 2015 and to Principal in 2020. Among her leading roles with the Company are Giselle in Giselle, Medora in Le Corsaire, Kitri in Don Quixote, Odette/Odile in Swan Lake, Gamzatti in La Bayadere, Olga in Onegin, Clara, the Princess in The Nutcracker, Young Jane in Jane Eyre, Columbine in Harlequinade, Princess Praline in Whipped Cream, the Lead Maiden in Firebird, the Golden Cockerel in The Golden Cockerel, and roles in The Green Table, Pillar of Fire, The Sleeping Beauty, Bach Partita, The Brahms-Haydn Variations, Company B, Gong, In the Upper Room, Piano Concerto #1, Raymonda Divertissements, Sinfonietta, Symphonic Variations, and AFTERITE.

Brandt was awarded a 2013 Princess Grace Foundation-USA Dance Fellowship. That same year, she was featured in the movie “Ballet’s Greatest Hits”. In 2018, Brandt was the recipient of an unprecedented Special Jury Award for her performances on the Russian television show “Big Ballet”. In 2022, Brandt was named to the renowned "Forbes 30 Under 30" list of most influential leaders and entrepreneurs.